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»immense difficulties
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»important business
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»important cases
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»important issue
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»important items
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»important problem
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»important respects
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»important subjects
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»important topics
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»in a jam
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»in bad trouble
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»in danger
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»in deep trouble
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»in hot water
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»in real trouble
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»in really big trouble
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»in serious trouble
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»in the lurch
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»into trouble
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»key points
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